Ontology highlight
ABSTRACT:
SUBMITTER: Pallasch CP
PROVIDER: S-EPMC2925729 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Pallasch Christian Philipp CP Patz Michaela M Park Yoon Jung YJ Hagist Susanne S Eggle Daniela D Claus Rainer R Debey-Pascher Svenja S Schulz Alexandra A Frenzel Lukas P LP Claasen Julia J Kutsch Nadine N Krause Günter G Mayr Christine C Rosenwald Andreas A Plass Christoph C Schultze Joachim L JL Hallek Michael M Wendtner Clemens-Martin CM
Blood 20090819 15
MicroRNAs (miRNA) play a key role in cellular regulation and, if deregulated, in the development of neoplastic disorders including chronic lymphocytic leukemia (CLL). RNAs from primary cells of 50 treatment-naive CLL patients and peripheral B cells of 14 healthy donors were applied to miRNA expression profiling using bead chip technology. In CLL cells, a set of 7 up- and 19 down-regulated miRNAs was identified. Among the miRNAs down-regulated in CLL cells, 6 of 10 miRNA promoters examined showed ...[more]