Ontology highlight
ABSTRACT:
SUBMITTER: Hanoun M
PROVIDER: S-EPMC3314606 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Hanoun Maher M Eisele Lewin L Suzuki Masako M Greally John M JM Hüttmann Andreas A Aydin Semra S Scholtysik René R Klein-Hitpass Ludger L Dührsen Ulrich U Dürig Jan J
PloS one 20120328 3
Disruption of circadian rhythm is believed to play a critical role in cancer development. Cryptochrome 1 (CRY1) is a core component of the mammalian circadian clock and we have previously shown its deregulated expression in a subgroup of patients with chronic lymphocytic leukemia (CLL). Using real-time RT-PCR in a cohort of 76 CLL patients and 35 normal blood donors we now demonstrate that differential CRY1 mRNA expression in high-risk (HR) CD38+/immunoglobulin variable heavy chain gene (IgVH) u ...[more]