ALOX12 gene is associated with the onset of natural menopause in white women.

ABSTRACT:

Objective

Natural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many postmenopausal systemic disorders and may thus influence life expectancy. Age at natural menopause (ANM) is largely determined genetically, but a list of candidate genes is far from complete. This study investigated the ALOX12 gene for its possible association with ANM.

Methods

Six single-nucleotide polymorphisms (SNPs) of the gene (rs9904779, rs2073438, rs11571340, rs434473, rs2307214, and rs312462) were genotyped in a random sample of 210 unrelated white women. The SNPs and common haplotypes were then analyzed for their association with ANM. Smoking, alcohol consumption, and duration of breast-feeding were used as covariates.

Results

Two SNPs, rs9904

SUBMITTER: Liu P 

PROVIDER: S-EPMC2927106 | biostudies-literature | 2010 Jan-Feb

REPOSITORIES: biostudies-literature