Ontology highlight
ABSTRACT:
SUBMITTER: Groseclose MR
PROVIDER: S-EPMC2927989 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Groseclose M Reid MR Massion Pierre P PP Chaurand Pierre P Caprioli Richard M RM
Proteomics 20080901 18
A novel method for high-throughput proteomic analysis of formalin-fixed paraffin-embedded (FFPE) tissue microarrays (TMA) is described using on-tissue tryptic digestion followed by MALDI imaging MS. A TMA section containing 112 needle core biopsies from lung-tumor patients was analyzed using MS and the data were correlated to a serial hematoxylin and eosin (H&E)-stained section having various histological regions marked, including cancer, non-cancer, and normal ones. By correlating each mass spe ...[more]