Ontology highlight
ABSTRACT:
SUBMITTER: Lauffer BE
PROVIDER: S-EPMC2928020 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Lauffer Benjamin E L BE Melero Cristina C Temkin Paul P Lei Cai C Hong Wanjin W Kortemme Tanja T von Zastrow Mark M
The Journal of cell biology 20100801 4
Postsynaptic density 95/discs large/zonus occludens-1 (PDZ) domain-interacting motifs, in addition to their well-established roles in protein scaffolding at the cell surface, are proposed to act as cis-acting determinants directing the molecular sorting of transmembrane cargo from endosomes to the plasma membrane. This hypothesis requires the existence of a specific trans-acting PDZ protein that mediates the proposed sorting operation in the endosome membrane. Here, we show that sorting nexin 27 ...[more]