Ontology highlight
ABSTRACT:
SUBMITTER: Singh V
PROVIDER: S-EPMC6127729 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Singh Varsha V Yang Jianbo J Yin Jianyi J Cole Robert R Tse Ming M Berman Diego E DE Small Scott A SA Petsko Gregory G Donowitz Mark M
Journal of cell science 20180817 16
Cholera toxin (CT) causes severe diarrhea by increasing intracellular cAMP leading to a PKA-dependent increase in Cl<sup>-</sup> secretion through CFTR and decreased Na<sup>+</sup> absorption through inhibition of Na<sup>+</sup>/H<sup>+</sup> exchanger 3 (NHE3; also known as SLC9A3). The mechanism(s) by which CT inhibits NHE3 is partially understood, although no drug therapy has been successful at reversing this inhibition. We now describe that CT phosphorylates an amino acid in the PDZ domain o ...[more]