Ontology highlight
ABSTRACT:
SUBMITTER: Sharpe HJ
PROVIDER: S-EPMC2928124 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Sharpe Hayley J HJ Stevens Tim J TJ Munro Sean S
Cell 20100701 1
The various membranes of eukaryotic cells differ in composition, but it is at present unclear if this results in differences in physical properties. The sequences of transmembrane domains (TMDs) of integral membrane proteins should reflect the physical properties of the bilayers in which they reside. We used large datasets from both fungi and vertebrates to perform a comprehensive comparison of the TMDs of proteins from different organelles. We find that TMDs are not generic but have organelle-s ...[more]