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Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women.


ABSTRACT:

Objective

To determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes.

Research design and methods

In a nested case-control study conducted among 608 women with newly diagnosed type 2 diabetes and 559 control subjects in the Nurses' Health Study, we measured the association between baseline plasma 25-OHD concentration and risk of incident diabetes.

Results

After adjusting for matching factors and diabetes risk factors, including BMI, higher levels of plasma 25-OHD were associated with a lower risk for type 2 diabetes. The odds ratio for incident type 2 diabetes in the top (median 25-OHD, 33.4 ng/ml) versus the bottom (median 25-OHD, 14.4 ng/ml) quartile was 0.52 (95% CI 0.33-0.83). The associations were consistent across subgroups of baseline BMI, age, and calcium intake.

Conclusions

Plasma 25-OHD concentration was associated with lower risk of incident type 2 diabetes in women.

SUBMITTER: Pittas AG 

PROVIDER: S-EPMC2928356 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Publications

Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women.

Pittas Anastassios G AG   Sun Qi Q   Manson Joann E JE   Dawson-Hughes Bess B   Hu Frank B FB  

Diabetes care 20100901 9


<h4>Objective</h4>To determine the association between 25-hydroxyvitamin D (25-OHD) concentration and risk of incident type 2 diabetes.<h4>Research design and methods</h4>In a nested case-control study conducted among 608 women with newly diagnosed type 2 diabetes and 559 control subjects in the Nurses' Health Study, we measured the association between baseline plasma 25-OHD concentration and risk of incident diabetes.<h4>Results</h4>After adjusting for matching factors and diabetes risk factors  ...[more]

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