Ontology highlight
ABSTRACT:
SUBMITTER: Norris JM
PROVIDER: S-EPMC5741144 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Norris Jill M JM Lee Hye-Seung HS Frederiksen Brittni B Erlund Iris I Uusitalo Ulla U Yang Jimin J Lernmark Åke Å Simell Olli O Toppari Jorma J Rewers Marian M Ziegler Anette-G AG She Jin-Xiong JX Onengut-Gumuscu Suna S Chen Wei-Min WM Rich Stephen S SS Sundvall Jouko J Akolkar Beena B Krischer Jeffrey J Virtanen Suvi M SM Hagopian William W
Diabetes 20171023 1
We examined the association between plasma 25-hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested case-control study of 376 IA case subjects and up to ...[more]