Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.
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ABSTRACT:
SUBMITTER: LaPlant Q
PROVIDER: S-EPMC2928863 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens.
LaPlant Quincey Q Vialou Vincent V Covington Herbert E HE Dumitriu Dani D Feng Jian J Warren Brandon L BL Maze Ian I Dietz David M DM Watts Emily L EL Iñiguez Sergio D SD Koo Ja Wook JW Mouzon Ezekiell E Renthal William W Hollis Fiona F Wang Hui H Noonan Michele A MA Ren Yanhua Y Eisch Amelia J AJ Bolaños Carlos A CA Kabbaj Mohamed M Xiao Guanghua G Neve Rachael L RL Hurd Yasmin L YL Oosting Ronald S RS Fan Gouping G Morrison John H JH Nestler Eric J EJ
Nature neuroscience 20100822 9
Despite abundant expression of DNA methyltransferases (Dnmts) in brain, the regulation and behavioral role of DNA methylation remain poorly understood. We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use and chronic social defeat stress. Moreover, NAc-specific manipulations that block DNA methylation potentiated cocaine reward and exerted antidepressant-like effects, whereas NAc-specific Dnmt3a overexpression attenuated cocaine reward and was pro ...[more]
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