Adeno-associated virus vector integration.
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ABSTRACT:
SUBMITTER: Deyle DR
PROVIDER: S-EPMC2929125 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Publications
Adeno-associated virus vector integration.
Deyle David R DR Russell David W DW
Current opinion in molecular therapeutics 20090801 4
Adeno-associated virus (AAV) vectors efficiently transduce various cell types and can produce long-term expression of transgenes in vivo. Although AAV vector genomes can persist within cells as episomes, vector integration has been observed in various experimental settings, either at non-homologous sites where DNA damage may have occurred or by homologous recombination. In some cases, integration is essential for the therapeutic or experimental efficacy of AAV vectors. Recently, insertional muta ...[more]
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