Ontology highlight
ABSTRACT:
SUBMITTER: Rutledge EA
PROVIDER: S-EPMC192305 | biostudies-other | 1997 Nov
REPOSITORIES: biostudies-other
Rutledge E A EA Russell D W DW
Journal of virology 19971101 11
Vectors derived from adeno-associated virus (AAV) have the potential to stably transduce mammalian cells by integrating into host chromosomes. Despite active research on the use of AAV vectors for gene therapy, the structure of integrated vector proviruses has not previously been analyzed at the DNA sequence level. Studies on the integration of wild-type AAV have identified a common site-specific integration locus on human chromosome 19; however, most AAV vectors do not appear to integrate at th ...[more]