Ontology highlight
ABSTRACT:
SUBMITTER: Wipf P
PROVIDER: S-EPMC2929370 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Wipf Peter P Mo Tingting T Geib Steven J SJ Caridha Diana D Dow Geoffrey S GS Gerena Lucia L Roncal Norma N Milner Erin E EE
Organic & biomolecular chemistry 20090807 20
Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines. ...[more]