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Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.

ABSTRACT: Pentafluorosulfanyl-containing analogs of flufenamic acid have been synthesized in high yields. Computationally, pKa, LogP and LogD values have been determined. Initial bioactivity studies reveal effects as ion channel modulators and inhibitory activities on aldo-keto reductase 1C3 (AKR1C3) as well as COX-1 and COX-2.

SUBMITTER: Hendriks CM

PROVIDER: S-EPMC4599580 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities.

Hendriks Christine M M CM Penning Trevor M TM Zang Tianzhu T Wiemuth Dominik D Gründer Stefan S Sanhueza Italo A IA Schoenebeck Franziska F Bolm Carsten C

Bioorganic & medicinal chemistry letters 20150908 20

Pentafluorosulfanyl-containing analogs of flufenamic acid have been synthesized in high yields. Computationally, pKa, LogP and LogD values have been determined. Initial bioactivity studies reveal effects as ion channel modulators and inhibitory activities on aldo-keto reductase 1C3 (AKR1C3) as well as COX-1 and COX-2. ...[more]

PMID: 26372652

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