Ontology highlight
ABSTRACT:
SUBMITTER: Dasari M
PROVIDER: S-EPMC2929653 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Dasari Madhuri M Lee Sungmun S Sy Jay J Kim Dongin D Lee Seungjun S Brown Milton M Davis Michael M Murthy Niren N
Organic letters 20100801 15
Cell necrosis is central to the progression of numerous diseases, and imaging agents that can detect necrotic tissue have great clinical potential. We demonstrate here that a small molecule, termed Hoechst-IR, composed of the DNA binding dye Hoechst and the near-infrared dye IR-786, can image necrotic tissue in vivo via fluorescence imaging. Hoechst-IR detects necrosis by binding extracellular DNA released from necrotic cells and was able to image necrosis generated from a myocardial infarction ...[more]