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Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.


ABSTRACT: Cell necrosis is central to the progression of numerous diseases, and imaging agents that can detect necrotic tissue have great clinical potential. We demonstrate here that a small molecule, termed Hoechst-IR, composed of the DNA binding dye Hoechst and the near-infrared dye IR-786, can image necrotic tissue in vivo via fluorescence imaging. Hoechst-IR detects necrosis by binding extracellular DNA released from necrotic cells and was able to image necrosis generated from a myocardial infarction and lipopolysaccharide/d-galactosamine (LPS-GalN) induced sepsis.

SUBMITTER: Dasari M 

PROVIDER: S-EPMC2929653 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Hoechst-IR: an imaging agent that detects necrotic tissue in vivo by binding extracellular DNA.

Dasari Madhuri M   Lee Sungmun S   Sy Jay J   Kim Dongin D   Lee Seungjun S   Brown Milton M   Davis Michael M   Murthy Niren N  

Organic letters 20100801 15


Cell necrosis is central to the progression of numerous diseases, and imaging agents that can detect necrotic tissue have great clinical potential. We demonstrate here that a small molecule, termed Hoechst-IR, composed of the DNA binding dye Hoechst and the near-infrared dye IR-786, can image necrotic tissue in vivo via fluorescence imaging. Hoechst-IR detects necrosis by binding extracellular DNA released from necrotic cells and was able to image necrosis generated from a myocardial infarction  ...[more]

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