Ontology highlight
ABSTRACT:
SUBMITTER: Kim E
PROVIDER: S-EPMC4772718 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Bioconjugate chemistry 20150609 8
Bruton's tyrosine kinase (Btk) is intricately involved in anti-apoptotic signaling pathways in cancer and in regulating innate immune response. A number of Btk inhibitors are in development for use in treating B-cell malignancies and certain immunologic diseases. To develop robust companion imaging diagnostics for in vivo use, we set out to explore the effects of red wavelength fluorochrome modifications of two highly potent irreversible Btk inhibitors, Ibrutinib and AVL-292. Surprisingly, we fo ...[more]