Ontology highlight
ABSTRACT:
SUBMITTER: Spadafora D
PROVIDER: S-EPMC2929888 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Spadafora Domenico D Hawkins Eleanor C EC Murphy Keith E KE Clark Leigh Anne LA Ballard Stephen T ST
Physiological genomics 20100622 3
Naturally occurring cystic fibrosis (CF)-causing mutations in the CFTR gene have not been identified in any nonhuman animal species. Since domestic dogs are known to develop medical conditions associated with atypical CF in humans (e.g., bronchiectasis and pancreatitis), we hypothesized that dogs with these disorders likely have a higher expression rate of CFTR mutations than the at-large population. Temporal temperature-gradient gel electrophoresis (TTGE) was used to screen canine CFTR in 400 a ...[more]