Ontology highlight
ABSTRACT:
SUBMITTER: Siatecka M
PROVIDER: S-EPMC2930539 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Siatecka Miroslawa M Sahr Kenneth E KE Andersen Sabra G SG Mezei Mihaly M Bieker James J JJ Peters Luanne L LL
Proceedings of the National Academy of Sciences of the United States of America 20100809 34
Studies of mouse models of anemia have long provided fundamental insights into red blood cell formation and function. Here we show that the semidominant mouse mutation Nan ("neonatal anemia") carries a single amino acid change (E339D) within the second zinc finger of the erythroid Krüppel-like factor (EKLF), a critical erythroid regulatory transcription factor. The mutation alters the DNA-binding specificity of EKLF so that it no longer binds promoters of a subset of its DNA targets. Remarkably, ...[more]