Redox cycling in iron uptake, efflux, and trafficking.
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ABSTRACT:
SUBMITTER: Kosman DJ
PROVIDER: S-EPMC2930670 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Publications
Redox cycling in iron uptake, efflux, and trafficking.
The Journal of biological chemistry 20100603 35
Aerobic organisms are faced with a dilemma. Environmental iron is found primarily in the relatively inert Fe(III) form, whereas the more metabolically active ferrous form is a strong pro-oxidant. This conundrum is solved by the redox cycling of iron between Fe(III) and Fe(II) at every step in the iron metabolic pathway. As a transition metal ion, iron can be "metabolized" only by this redox cycling, which is catalyzed in aerobes by the coupled activities of ferric iron reductases (ferrireductase ...[more]
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