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Iron and porphyrin trafficking in heme biogenesis.

ABSTRACT: Iron is an essential element for diverse biological functions. In mammals, the majority of iron is enclosed within a single prosthetic group: heme. In metazoans, heme is synthesized via a highly conserved and coordinated pathway within the mitochondria. However, iron is acquired from the environment and subsequently assimilated into various cellular pathways, including heme synthesis. Both iron and heme are toxic but essential cofactors. How is iron transported from the extracellular milieu to the mitochondria? How are heme and heme intermediates coordinated with iron transport? Although recent studies have answered some questions, several pieces of this intriguing puzzle remain unsolved.

SUBMITTER: Schultz IJ

PROVIDER: S-EPMC2930673 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Iron and porphyrin trafficking in heme biogenesis.

Schultz Iman J IJ Chen Caiyong C Paw Barry H BH Hamza Iqbal I

The Journal of biological chemistry 20100603 35

Iron is an essential element for diverse biological functions. In mammals, the majority of iron is enclosed within a single prosthetic group: heme. In metazoans, heme is synthesized via a highly conserved and coordinated pathway within the mitochondria. However, iron is acquired from the environment and subsequently assimilated into various cellular pathways, including heme synthesis. Both iron and heme are toxic but essential cofactors. How is iron transported from the extracellular milieu to t ...[more]

PMID: 20522548

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