Ontology highlight
ABSTRACT:
SUBMITTER: Chen YL
PROVIDER: S-EPMC2930731 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Chen Yen-Ling YL Eriksson Staffan S Chang Zee-Fen ZF
The Journal of biological chemistry 20100616 35
Cellular supply of dNTPs is essential in the DNA replication and repair processes. Here we investigated the regulation of thymidine kinase 1 (TK1) in response to DNA damage and found that genotoxic insults in tumor cells cause up-regulation and nuclear localization of TK1. During recovery from DNA damage, TK1 accumulates in p53-null cells due to a lack of mitotic proteolysis as these cells are arrested in the G(2) phase by checkpoint activation. We show that in p53-proficient cells, p21 expressi ...[more]