Ontology highlight
ABSTRACT:
SUBMITTER: Wang ZX
PROVIDER: S-EPMC10218208 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Wang Zhong-Xuan ZX Liu Yi Y Li Yao-Lin YL Wei Qiao Q Lin Rong-Rong RR Kang Ruiqing R Ruan Yang Y Lin Zhi-Hao ZH Xue Nai-Jia NJ Zhang Bao-Rong BR Pu Jia-Li JL
International journal of molecular sciences 20230512 10
DNA damage and defective DNA repair are extensively linked to neurodegeneration in Parkinson's disease (PD), but the underlying molecular mechanisms remain poorly understood. Here, we determined that the PD-associated protein DJ-1 plays an essential role in modulating DNA double-strand break (DSB) repair. Specifically, DJ-1 is a DNA damage response (DDR) protein that can be recruited to DNA damage sites, where it promotes DSB repair through both homologous recombination and nonhomologous end joi ...[more]