Ontology highlight
ABSTRACT:
SUBMITTER: Meyer KD
PROVIDER: S-EPMC2932482 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Meyer Krista D KD Lin Shih-Chieh SC Bernecky Carrie C Gao Yuefeng Y Taatjes Dylan J DJ
Nature structural & molecular biology 20100509 6
It is not well understood how the human Mediator complex, transcription factor IIH and RNA polymerase II (Pol II) work together with activators to initiate transcription. Activator binding alters Mediator structure, yet the functional consequences of such structural shifts remain unknown. The p53 C terminus and its activation domain interact with different Mediator subunits, and we find that each interaction differentially affects Mediator structure; strikingly, distinct p53-Mediator structures ...[more]