Ontology highlight
ABSTRACT:
SUBMITTER: Tanikawa C
PROVIDER: S-EPMC3306259 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Tanikawa Chizu C Nakagawa Hidewaki H Furukawa Yoichi Y Nakamura Yusuke Y Matsuda Koichi K
Neoplasia (New York, N.Y.) 20120201 2
p53 is a tumor suppressor gene that is frequently mutated in multiple cancer tissues. Activated p53 protein regulates its downstream genes and subsequently inhibits malignant transformation by inducing cell cycle arrest, apoptosis, DNA repair, and senescence. However, genes involved in the p53-mediated senescence pathway are not yet fully elucidated. Through the screening of two genome-wide expression profile data sets, one for cells in which exogenous p53 was introduced and the other for senesc ...[more]