Ontology highlight
ABSTRACT:
SUBMITTER: Almond D
PROVIDER: S-EPMC2932551 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
AIDS research and human retroviruses 20100601 6
The diversity of HIV-1 is a confounding problem for vaccine design, as the human immune response appears to favor poor or strain-specific responses to any given HIV-1 virus strain. A significant portion of this diversity is manifested as sequence variability in the loops of HIV-1's surface envelope glycoprotein. Here we show that the most variable sequence positions in the third variable (V3) loop crown cluster to a small zone on the surface of one face of the V3 loop ss-hairpin conformation. Th ...[more]