Ontology highlight
ABSTRACT:
SUBMITTER: Chan KW
PROVIDER: S-EPMC8578649 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Chan Kun-Wei KW Luo Christina C CC Lu Hong H Wu Xueling X Kong Xiang-Peng XP
Nature communications 20211109 1
Identification of vulnerable sites defined by broadly neutralizing antibodies (bNAbs) on HIV-1 envelope (Env) is crucial for vaccine design, and we present here a vulnerable site defined by bNAb M4008_N1, which neutralizes about 40% of a tier-2 virus panel. A 3.2 Å resolution cryo-EM structure of M4008_N1 in complex with BG505 DS-SOSIP reveals a large, shallow protein epitope surface centered at the V3 crown of gp120 and surrounded by key glycans. M4008_N1 interacts with gp120 primarily through ...[more]