Ontology highlight
ABSTRACT:
SUBMITTER: Kao DI
PROVIDER: S-EPMC2932564 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Kao Der-I DI Aldridge Georgina M GM Weiler Ivan Jeanne IJ Greenough William T WT
Proceedings of the National Academy of Sciences of the United States of America 20100816 35
Fragile X syndrome is caused by the absence of functional fragile X mental retardation protein (FMRP), an RNA binding protein. The molecular mechanism of aberrant protein synthesis in fmr1 KO mice is closely associated with the role of FMRP in mRNA transport, delivery, and local protein synthesis. We show that GFP-labeled Fmr1 and CaMKIIalpha mRNAs undergo decelerated motion at 0-40 min after group I mGluR stimulation, and later recover at 40-60 min. Then we investigate targeting of mRNAs associ ...[more]