Ontology highlight
ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC4447080 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Zhang Wenhua W Xu Chanjuan C Tu Haijun H Wang Yunyun Y Sun Qian Q Hu Ping P Hu Yongjian Y Rondard Philippe P Liu Jianfeng J
Scientific reports 20150528
Fragile X mental retardation protein (FMRP) is an RNA-binding protein important for the control of translation and synaptic function. The mutation or silencing of FMRP causes Fragile X syndrome (FXS), which leads to intellectual disability and social impairment. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter of the mammalian central nervous system, and its metabotropic GABAB receptor has been implicated in various mental disorders. The GABAB receptor agonist baclofen has bee ...[more]