Ontology highlight
ABSTRACT:
SUBMITTER: Mitra S
PROVIDER: S-EPMC2932750 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Mitra Sayantan S Duggineni Srinivas S Koolpe Mitchell M Zhu Xuejun X Huang Ziwei Z Pasquale Elena B EB
Biochemistry 20100801 31
The EphA2 receptor tyrosine kinase has emerged as a promising new therapeutic target in cancer because of its high level of expression in tumors. EphA2-specific antibodies have been used to deliver drugs and toxins to tumor cells, leading to inhibition of tumor growth and metastatic dissemination. We previously identified two related peptides, YSA and SWL, that selectively bind to the ligand-binding domain of EphA2 but not other Eph receptors and could therefore be useful as selective targeting ...[more]