Ontology highlight
ABSTRACT:
SUBMITTER: Molina JR
PROVIDER: S-EPMC2932801 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Molina Jennifer R JR Morales Fabiana C FC Hayashi Yuho Y Aldape Kenneth D KD Georgescu Maria-Magdalena MM
Cancer research 20100824 17
Glioblastoma multiforme (GBM) is a severe brain malignancy with limited treatment and dismal prognosis. The tumor suppressor PTEN, a major inhibitor of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway, is frequently deleted in GBM tumors. PTEN antagonizes PI3K by dephosphorylating PI3K phosphoinositide substrates at the plasma membrane. The PTEN binding adapter protein NHERF1/EBP50 is overexpressed in GBM but its effects on tumorigenesis have yet to be determined. Here, we show that NHERF ...[more]