Ontology highlight
ABSTRACT:
SUBMITTER: Ravikumar B
PROVIDER: S-EPMC2923063 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Ravikumar Brinda B Moreau Kevin K Jahreiss Luca L Puri Claudia C Rubinsztein David C DC
Nature cell biology 20100718 8
Autophagy is a catabolic process in which lysosomes degrade intracytoplasmic contents transported in double-membraned autophagosomes. Autophagosomes are formed by the elongation and fusion of phagophores, which derive from pre-autophagosomal structures. The membrane origins of autophagosomes are unclear and may involve multiple sources, including the endoplasmic reticulum and mitochondria. Here we show in mammalian cells that the heavy chain of clathrin interacts with Atg16L1 and is involved in ...[more]