Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC2932882 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Wang Wei W Wang Li L Li Xin-xiu XX Chen Xia X Zhang Hai-yan HY He Yu Y Wang Jing-jing JJ Zhao Yong-yan YY Zhang Bao-le BL Xu Yin-xue YX
Journal of Zhejiang University. Science. B 20100901 9
Bone morphogenetic proteins (BMPs) play a critical role in the growth and steroidogenesis of granulosa cells (GCs). BMP signals act through membrane-bound heteromeric serine/threonine kinase receptors. Upon ligand binding, BMPs activate intracellular Smad proteins and regulate growth and apoptosis in various cell types. The objective of this study was to demonstrate the effects of BMP/Smad signal on growth and steroidogenesis of porcine GCs. A strategy of RNA interference (RNAi)-mediated 'gene s ...[more]