Ontology highlight
ABSTRACT:
SUBMITTER: Olivieri KC
PROVIDER: S-EPMC2933169 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Olivieri Kevin C KC Agopian Kristin A KA Mukerji Joya J Gabuzda Dana D
AIDS research and human retroviruses 20100401 4
Human immunodeficiency virus type 1 (HIV) infection of the central nervous system frequently causes HIV-associated neurocognitive disorders (HAND). The role of HIV Nef and other accessory proteins in HAND pathogenesis is unclear. To determine whether HIV nef undergoes adaptive selection in brain, we cloned 100 nef sequences (n = 30 brain and n = 70 lymphoid) from four patients with AIDS and HIV-associated dementia (HAD). Normalized nonsynonymous substitutions were more frequent at the divergence ...[more]