Structural perspectives on secondary active transporters.
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ABSTRACT:
SUBMITTER: Boudker O
PROVIDER: S-EPMC2933288 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Structural perspectives on secondary active transporters.
Boudker Olga O Verdon Grégory G
Trends in pharmacological sciences 20100723 9
Secondary active transporters catalyze the concentrative transport of substrates across lipid membranes by harnessing the energy of electrochemical ion gradients. These transporters bind their ligands on one side of the membrane, and undergo a global conformational change to release them on the other side of the membrane. Over the last few years, crystal structures have captured several bacterial secondary transporters in different states along their transport cycle, providing insight into possi ...[more]
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