Structural diversity of ABC transporters.
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ABSTRACT:
SUBMITTER: ter Beek J
PROVIDER: S-EPMC3971661 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Structural diversity of ABC transporters.
ter Beek Josy J Guskov Albert A Slotboom Dirk Jan DJ
The Journal of general physiology 20140317 4
ATP-binding cassette (ABC) transporters form a large superfamily of ATP-dependent protein complexes that mediate transport of a vast array of substrates across membranes. The 14 currently available structures of ABC transporters have greatly advanced insight into the transport mechanism and revealed a tremendous structural diversity. Whereas the domains that hydrolyze ATP are structurally related in all ABC transporters, the membrane-embedded domains, where the substrates are translocated, adopt ...[more]
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