Ontology highlight
ABSTRACT:
SUBMITTER: Levy-Adam F
PROVIDER: S-EPMC2934666 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Levy-Adam Flonia F Feld Sari S Cohen-Kaplan Victoria V Shteingauz Anna A Gross Miriam M Arvatz Gil G Naroditsky Inna I Ilan Neta N Doweck Ilana I Vlodavsky Israel I
The Journal of biological chemistry 20100624 36
Heparanase activity is highly implicated in cell dissemination associated with tumor metastasis, angiogenesis, and inflammation. Heparanase expression is induced in many hematological and solid tumors, associated with poor prognosis. Heparanase homolog, termed heparanase 2 (Hpa2), was cloned based on sequence homology. Detailed characterization of Hpa2 at the biochemical, cellular, and clinical levels has not been so far reported, and its role in normal physiology and pathological disorders is o ...[more]