Ontology highlight
ABSTRACT:
SUBMITTER: Loka RS
PROVIDER: S-EPMC5590105 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Loka Ravi S RS Yu Fei F Sletten Eric T ET Nguyen Hien M HM
Chemical communications (Cambridge, England) 20170801 65
Heparanase is an enzyme which cleaves heparan sulfate (HS) polysaccharides of the extracellular matrix. It is a regulator of tumor behavior, plays a key role in kidney related diseases and autoimmune diabetes. We report herein the use of computational studies to extract the natural HS-heparanase interactions as a template for the design of HS mimicking glycopolymers. Upon evaluation, a glycopolymer with 12 repeating units was determined to be the most potent inhibitor and to have tight-binding c ...[more]