Ontology highlight
ABSTRACT:
SUBMITTER: Sakurai T
PROVIDER: S-EPMC2934701 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Sakurai Takanobu T Misaka Takumi T Ishiguro Masaji M Masuda Katsuyoshi K Sugawara Taishi T Ito Keisuke K Kobayashi Takuya T Matsuo Shinji S Ishimaru Yoshiro Y Asakura Tomiko T Abe Keiko K
The Journal of biological chemistry 20100706 36
G-protein-coupled receptors mediate the senses of taste, smell, and vision in mammals. Humans recognize thousands of compounds as bitter, and this response is mediated by the hTAS2R family, which is one of the G-protein-coupled receptors composed of only 25 receptors. However, structural information on these receptors is limited. To address the molecular basis of bitter tastant discrimination by the hTAS2Rs, we performed ligand docking simulation and functional analysis using a series of point m ...[more]