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Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient.

ABSTRACT: Three of seven clonally related Pseudomonas aeruginosa strains isolated from a burn patient produced the extended-spectrum beta-lactamase (ESBL) SHV-12. Its gene was flanked by two IS26 elements with a large transposon (>24 kb). The transposon also contained at least five IS26 elements and a gene encoding the amikacin resistance determinant aminoglycoside 6'-N-acetyltransferase type Ib [aac(6')-Ib]. It was inserted into the gene PA5317 in the P. aeruginosa chromosome.

SUBMITTER: Uemura S

PROVIDER: S-EPMC2934948 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Acquisition of a transposon encoding extended-spectrum beta-lactamase SHV-12 by Pseudomonas aeruginosa isolates during the clinical course of a burn patient.

Uemura Shuji S Yokota Shin-ichi S Mizuno Hirotoshi H Sakawaki Eiji E Sawamoto Keigo K Maekawa Kunihiko K Tanno Katsutoshi K Mori Kazuhisa K Asai Yasufumi Y Fujii Nobuhiro N

Antimicrobial agents and chemotherapy 20100621 9

Three of seven clonally related Pseudomonas aeruginosa strains isolated from a burn patient produced the extended-spectrum beta-lactamase (ESBL) SHV-12. Its gene was flanked by two IS26 elements with a large transposon (>24 kb). The transposon also contained at least five IS26 elements and a gene encoding the amikacin resistance determinant aminoglycoside 6'-N-acetyltransferase type Ib [aac(6')-Ib]. It was inserted into the gene PA5317 in the P. aeruginosa chromosome. ...[more]

PMID: 20566763

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An SHV-derived extended-spectrum beta-lactamase in Pseudomonas aeruginosa.

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