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In vitro and in vivo studies of single-walled carbon nanohorns with encapsulated metallofullerenes and exohedrally functionalized quantum dots.

ABSTRACT: Single-walled carbon nanohorns (SWNHs) are new carbonaceous materials. In this paper, we report the first successful preparation of SWNHs encapsulating trimetallic nitride template endohedral metallofullerenes (TNT-EMFs). The resultant materials were functionalized by a high-speed vibration milling method and conjugated with CdSe/ZnS quantum dots (QDs). The successful encapsulation of TNT-EMFs and external functionalization with QDs provide a dual diagnostic platform for in vitro and in vivo biomedical applications of these new carbonaceous materials.

SUBMITTER: Zhang J

PROVIDER: S-EPMC2935139 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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In vitro and in vivo studies of single-walled carbon nanohorns with encapsulated metallofullerenes and exohedrally functionalized quantum dots.

Zhang Jianfei J Ge Jiechao J Shultz Michael D MD Chung Eunna E Singh Gurpreet G Shu Chunying C Fatouros Panos P PP Henderson Scott C SC Corwin Frank D FD Geohegan David B DB Puretzky Alex A AA Rouleau Christopher M CM More Karren K Rylander Christopher C Rylander Marissa Nichole MN Gibson Harry W HW Dorn Harry C HC

Nano letters 20100801 8

Single-walled carbon nanohorns (SWNHs) are new carbonaceous materials. In this paper, we report the first successful preparation of SWNHs encapsulating trimetallic nitride template endohedral metallofullerenes (TNT-EMFs). The resultant materials were functionalized by a high-speed vibration milling method and conjugated with CdSe/ZnS quantum dots (QDs). The successful encapsulation of TNT-EMFs and external functionalization with QDs provide a dual diagnostic platform for in vitro and in vivo bio ...[more]

PMID: 20698597

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