Expression of cancer-testis (CT) antigens in placenta.
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ABSTRACT:
SUBMITTER: Jungbluth AA
PROVIDER: S-EPMC2935757 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Publications
Expression of cancer-testis (CT) antigens in placenta.
Jungbluth Achim A AA Silva Wilson A WA Iversen Kristin K Frosina Denise D Zaidi Bushra B Coplan Keren K Eastlake-Wade Susannah K SK Castelli Sandra B SB Spagnoli Giulio C GC Old Lloyd J LJ Vogel Martin M
Cancer immunity 20070824
Besides their variable presence in fetal and adult germ cells, CT antigens have occasionally been detected in placental tissue. However, these data are scarce and solely based on mRNA analyses; nothing is known about their presence at the protein level. Here, we analyzed the expression of various CT antigens in placental tissues from gestational age week 5 to week 42 using monoclonal antibodies to various antigens of the MAGE-A and -C families, NY-ESO-1, as well as GAGE. We show that CT antigen ...[more]
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