Ontology highlight
ABSTRACT:
SUBMITTER: Kulkarni P
PROVIDER: S-EPMC3477645 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Kulkarni Prakash P Shiraishi Takumi T Rajagopalan Krithika K Kim Robert R Mooney Steven M SM Getzenberg Robert H RH
Nature reviews. Urology 20120619 7
Cancer/testis antigens (CTAs) are a group of tumour-associated antigens (TAAs) that display normal expression in the adult testis--an immune-privileged organ--but aberrant expression in several types of cancers, particularly in advanced cancers with stem cell-like characteristics. There has been an explosion in CTA-based research since CTAs were first identified in 1991 and MAGE-1 was shown to elicit an autologous cytotoxic T-lymphocyte (CTL) response in a patient with melanoma. The resulting da ...[more]