Ontology highlight
ABSTRACT:
SUBMITTER: Qiu H
PROVIDER: S-EPMC2936100 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Qiu Hongyu H Zhu Yi Y Sun Zhe Z Trzeciakowski Jerome P JP Gansner Meredith M Depre Christophe C Resuello Ranillo R G RR Natividad Filipinas F FF Hunter William C WC Genin Guy M GM Elson Elliot L EL Vatner Dorothy E DE Meininger Gerald A GA Vatner Stephen F SF
Circulation research 20100715 5
<h4>Rationale</h4>Increased aortic stiffness, an important feature of many vascular diseases, eg, aging, hypertension, atherosclerosis, and aortic aneurysms, is assumed because of changes in extracellular matrix (ECM).<h4>Objective</h4>We tested the hypothesis that the mechanisms also involve intrinsic stiffening of vascular smooth muscle cells (VSMCs).<h4>Methods and results</h4>Stiffness was measured in vitro both by atomic force microscopy (AFM) and in a reconstituted tissue model, using VSMC ...[more]