Ontology highlight
ABSTRACT:
SUBMITTER: Yang D
PROVIDER: S-EPMC3303600 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Yang Dan D McCrann Donald J DJ Nguyen Hao H St Hilaire Cynthia C DePinho Ronald A RA Jones Matthew R MR Ravid Katya K
Aging cell 20070207 2
We previously reported that the frequency of polyploid aortic vascular smooth muscle cells (VSMC) serves as a biomarker of aging. Cellular senescence of somatic cells is another marker of aging that is characterized by the inability to undergo cell division. Here, we examined whether polyploidy is associated with the development of cellular senescence in vivo. Analysis of aortic tissue preparations from young and old Brown Norway rats showed that expression of senescence markers such as p16(INK4 ...[more]