Cpd-1 null mice display a subtle neurological phenotype.
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ABSTRACT:
SUBMITTER: Kular RK
PROVIDER: S-EPMC2936576 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Publications
Cpd-1 null mice display a subtle neurological phenotype.
Kular Rupinder K RK Gogliotti Rocky G RG Opal Puneet P
PloS one 20100909 9
<h4>Background</h4>CPD1 (also known as ANP32-E) belongs to a family of evolutionarily conserved acidic proteins with leucine rich repeats implicated in a variety of cellular processes regulating gene expression, vesicular trafficking, intracellular signaling and apoptosis. Because of its spatiotemporal expression pattern, CPD1 has been proposed to play an important role in brain morphogenesis and synaptic development.<h4>Methodology/principal findings</h4>We have generated CPD1 knock-out mice th ...[more]
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