Ontology highlight
ABSTRACT:
SUBMITTER: Wright RD
PROVIDER: S-EPMC5295850 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Wright Rachael D RD Souza Patricia R PR Flak Magdalena B MB Thedchanamoorthy Prasheetha P Norling Lucy V LV Cooper Dianne D
Journal of leukocyte biology 20161012 3
Galectin-3 has been associated with a plethora of proinflammatory functions because of its ability, among others, to promote neutrophil activation and because of the reduction in neutrophil recruitment in models of infection in Gal-3-null mice. Conversely, it has also been linked to resolution of inflammation through its actions as an opsonin and its ability to promote efferocytosis of apoptotic neutrophils. Using a self-resolving model of peritonitis, we have addressed the modulation and role o ...[more]