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Genome scan for locus involved in mandibular prognathism in pedigrees from China.


ABSTRACT: BACKGROUND: It is well known that genetic components play an important role in the etiology of mandibular prognathism, but few susceptibility loci have been mapped. METHODOLOGY: In order to identify linkage regions for mandibular prognathism, we analyzed two Chinese pedigrees with 6,090 genome-wide single-nucleotide polymorphism (SNP) markers from Illumina Linkage-12 DNA Analysis Kit (average spacing 0.58 cM). Multipoint parametric and non-parametric (model-free) linkage analyses were used for the pedigrees. PRINCIPAL FINDING: The most statistically significant linkage results were with markers on chromosome 4 (LOD=3.166 and NPL=3.65 with rs 875864, 4p16.1, 8.38 cM). Candidate genes within the 4p16.1 include EVC, EVC2. CONCLUSION: We detected a novel suggestive linkage locus for mandibular prognathism in two Chinese pedigrees, and this linkage region provides target for susceptibility gene identification, a process that will provide important insights into the molecular and cellular basis of mandibular prognathism.

SUBMITTER: Li Q 

PROVIDER: S-EPMC2937026 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature

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Genome scan for locus involved in mandibular prognathism in pedigrees from China.

Li Qin Q   Zhang Feng F   Li Xin X   Chen Fengshan F  

PloS one 20100910 9


<h4>Background</h4>It is well known that genetic components play an important role in the etiology of mandibular prognathism, but few susceptibility loci have been mapped.<h4>Methodology</h4>In order to identify linkage regions for mandibular prognathism, we analyzed two Chinese pedigrees with 6,090 genome-wide single-nucleotide polymorphism (SNP) markers from Illumina Linkage-12 DNA Analysis Kit (average spacing 0.58 cM). Multipoint parametric and non-parametric (model-free) linkage analyses we  ...[more]

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