Relationship between P561T and C422F polymorphisms in growth hormone receptor gene and mandibular prognathism.

ABSTRACT:

Objective

To evaluate the allele and genotype frequencies of the P561T and C422F polymorphic sites of the growth hormone receptor (GHR) gene and the relationship between mandibular prognathism (MP) and these two single-nucleotide polymorphisms (SNPs).

Materials and methods

A total of 99 subjects with severe skeletal Class III MP who planned to undergo orthognathic surgery and 99 subjects with Class I occlusion were examined in this study to evaluate the relationship between MP and two SNPs in exon 10 of the GHR gene. GHR was chosen as a candidate gene because growth hormone plays an important role in cartilage growth. A blood sample was used to extract genomic DNA, and the polymerase chain reaction-restriction fragment length polymorphism method was used to determine genotyp

SUBMITTER: Bayram S 

PROVIDER: S-EPMC8641272 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature