Expression and physiological role of three Myxococcus xanthus copper-dependent P1B-type ATPases during bacterial growth and development.

ABSTRACT: Myxococcus xanthus is a soil-dwelling bacterium that exhibits a complex life cycle comprising social behavior, morphogenesis, and differentiation. In order to successfully complete this life cycle, cells have to cope with changes in their environment, among which the presence of copper is remarkable. Copper is an essential transition metal for life, but an excess of copper provokes cellular damage by oxidative stress. This dual effect forces the cells to maintain a tight homeostasis. M. xanthus encodes a large number of genes with similarities to others reported previously to be involved in copper homeostasis, most of which are redundant. We have identified three genes that encode copper-translocating P(1B)-ATPases (designated copA, copB, and copC) that exhibit the sequence motifs and modu

SUBMITTER: Moraleda-Munoz A 

PROVIDER: S-EPMC2937514 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature