Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC2937573 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Chen Huijun H Attieh Zouhair K ZK Syed Basharut A BA Kuo Yien-Ming YM Stevens Valerie V Fuqua Brie K BK Andersen Henriette S HS Naylor Claire E CE Evans Robert W RW Gambling Lorraine L Danzeisen Ruth R Bacouri-Haidar Mhenia M Usta Julnar J Vulpe Chris D CD McArdle Harry J HJ
The Journal of nutrition 20100804 10
We previously detected a membrane-bound, copper-containing oxidase that may be involved in iron efflux in BeWo cells, a human placental cell line. We have now identified a gene encoding a predicted multicopper ferroxidase (MCF) with a putative C-terminal membrane-spanning sequence and high sequence identity to hephaestin (Heph) and ceruloplasmin (Cp), the other known vertebrate MCF. Molecular modeling revealed conservation of all type I, II, and III copper-binding sites as well as a putative iro ...[more]